伊成器 Chengqi Yi

Address

School of Life Sciences, Peking University

5 Yiheyuan Road, Haidian District

Beijing 100871

P. R. China

Tel: 010-62752895. Email: chengqi.yi@pku.edu.cn

Born Jun. 19, 1983, in P. R. China

Education

• 09/2005 – 07/2010, University of Chicago, Ph.D. in Chemistry (with Prof. Chuan He)
• 09/2001 – 07/2005, University of Science and Technology of China, B.S. in Chemistry

Employment

• 08/2013 – present, Principal Investigator, Synthetic and Functional Biomolecules Center (SFBC), Peking University
• 01/2012 – present, Principal Investigator, Peking-Tsinghua Center for Life Sciences
• 01/2012 – present, School of Life Sciences, Peking University
• 08/2010 – 12/2011, Postdoctoral Fellow (with Prof. Tao Pan), University of Chicago

Awards

• 2014, Luye Eminent Young Scholar Award
• 2012, Nation Youth 1000 Plan Program
• 2011, IUPAC Prize for Young Chemists, International Union of Pure and Applied Chemistry
• 2009, Chemistry Alumni Graduate Fellowship, University of Chicago
• 2002, Zhang Zongzhi Sci-Tech Fellowship, University of Science and Technology of China

Professional Society Affiliations

• 2013 – present, the RNA society
• 2013 – present, the Chinese Society of Biochemistry and Molecular Biology
• 2012 – present, the Chinese Crystallographic Society
• 2012 – present, the Chinese Chemical Society

Research Interests

Epitranscriptomics · RNA modifications · DNA epigenetics · Chemical Biology · High-throughput Sequencing · Non-coding RNA

Representative Publications

1. Chenxu Zhu^#, Lining Lu^#, Jun Zhang^#, Zongwei Yue, Jinghui Song, Shuai Zong, Menghao Liu, Olivia Stovicek, Yi Qin Gao*, and Chengqi Yi*.(2016).Tautomerization-dependent Recognition and Excision of Oxidation Damage in Base-excision DNA Repair. Proc. Natl. Acad. Sci. U.S.A. 113(28), 7792. 

2. Xiaoyu Li^#, Xushen Xiong^#, Kun Wang, Lixia Wang, Xiaoting Shu, Shiqing Ma, Chengqi Yi*.(2016). Transcriptome-wide Mapping Reveals Reversible and Dynamic N(1)-methyladenosine Methylome. Nat. Chem. Biol. 12(5), 311.

3. Bo Xia^#, Dali Han^#, Xingyu Lu^#, Zhaozhu Sun, Ankun Zhou, Qiangzong Yin, Hu Zeng, Menghao Liu, Xiang Jiang, Wei Xie, Chuan He*, Chengqi Yi*.(2016). Bisulfite-free and Base-resolution Analysis of 5-formylcytosine at Whole-genome Scale. Nat. Methods. 12(11), 1047.

4. Xiaoyu Li^#, Ping Zhu^#, Shiqing Ma^#, Jinghui Song, Jinyi Bai, Fangfang Sun, Chengqi Yi*.(2015). Chemical Pull-Down Reveals Comprehensive and Dynamic Pseudouridylation in Mammalian Transcriptome. Nat. Chem. Biol. 11(8), 592.

5. John Karijolich J, Chengqi Yi, Yi-Tao Yu*. (2015). Transcriptome-wide Dynamics of RNA Pseudouridylation. Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm4040.

Before Joining Peking University:

6. Chengqi Yi, Baoen Chen, Bo Qi, Wen Zhang, Guifang Jia, Liang Zhang, Charles J. Li, Aaron Dinner, Cai-Guang Yang*, Chuan He*. (2012). Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage. Nat. Struct. Mol. Biol. 19(7), 671.

7. Chengqi Yi, Tao Pan*. (2011). Cellular Dynamics of RNA Modifications. Acc. Chem. Res. 44(12), 1380.

8. Chengqi Yi, Guifang Jia, Guanhua Hou, Qing Dai, Wen Zhang, Guanqun Zheng, Xing Jian, Cai-Guang Yang, Qiang Cui, Chuan He*. (2010). Iron-Catalysed Oxidation Intermediates Captured in a DNA Repair Dioxygenase. Nature, 468(7321), 330.

9. Chengqi Yi, Cai-Guang Yang, Chuan He*. (2009). A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA. Acc. Chem. Res. 42(4), 519.

10. Cai-Guang Yang^#, Chengqi Yi^#, Erica Duguid, Christopher Sullivan, Xing Jian, Phoebe Rice, Chuan He*. (2008). Crystal structures of DNA/RNA Repair Enzymes AlkB and ABH2 Bound to dsDNA. Nature, 452(7190), 961.